Effect of i.v. injection of CGP42112A (20 μg) on PGE2 (200 ng i.c.v.)-induced fever in rats
| Time (min) | |||||
|---|---|---|---|---|---|
| 0 | 30 | 60 | 90 | 120 | |
| °C | |||||
| aCSF + PGE2 | 37.21 ± 0.33 | 39.22 ± 0.26 | 38.48 ± 0.32 | 38.05 ± 0.29 | 38.36 ± 0.34 |
| CGP42112A + PGE2 | 37.27 ± 0.28 | 39.13 ± 0.26 | 38.37 ± 0.27 | 38.13 ± 0.34 | 38.26 ± 0.38 |
Changes (mean ± S.E.M.) in body temperature in rats after PGE2 (200 ng i.c.v.) administration at time 0. CGP42112A (20 μg, n = 3) or aCSF (n = 3) was injected i.v. immediately before the injection of PGE2.