Adenosine Analogs | +Endothelium | −Endothelium |
---|---|---|
NECA | 0.08 ± 0.02 | 2.1 ± 0.221-a |
CGS-21680 | 0.09 ± 0.02 | 1.90 ± 0.201-a |
CAD | 1.11 ± 0.18 | 1.41 ± 0.17 |
NECA indicates 5′-(N-ethylcarboxamide)adenosine; CGS-21680, 2-p-(2-carboxyethyl)phenylethyl-amino-5′N-ethylcarboxamidoadenosine and CAD, 2-chloroadenosine. Values are mean ± S.E.M. of data from 12 to 24 rings obtained from 4 to 8 pigs. Statistical analysis was carried out using Student’s t test.
↵1-a EC50 values for NECA and CGS-21680 in endothelium-denuded rings that are significantly different from corresponding values in endothelium-intact rings (P < .05).