Table 1

Effect of AdoMet administration on plasma concentrations of AdoMet, MeTHF, AdoHcy, homocysteine and methionine in healthy subjects (n = 14) and in controls (n = 3) without previous AdoMet administration; statistical significance: * and** = P < .05 and P < .001, respectively for difference between CO and Cmax

CO1-aCmax1-bWeight Adjusted Cmax-CO1-ctmax (hr)Weight Adjusted AUC1-d(nmol/liter*hr)
S-adenosylmethionine (nmol/liter)
 Loading
  Mean ± S.E.38.0  ± 13.4361.8  ± 66.4** 55.1  ± 11.84.3  ± 0.3194.8  ± 41.3
  Range 15.3–212.9 37.5–851.2  3.3–166.82.8–7.2 13.6–393.4
 Control
  Mean ± S.E.26.5  ± 5.839.6  ± 30.52.0  ± 1.414.0  ± 4.16.8  ± 2.0
  Range19.3–40.619.2–74.7−0.1–5.4  9.2–23.7 3.4–10.2
5-Methyltetrahydrofolate (nmol/liter)
 Loading
  Mean ± S.E.25.1  ± 2.536.2  ± 3.5** 1.8  ± 0.35.6  ± 0.312.0  ± 3.0
  Range13.2–45.018.5–63.50.5–3.63.2–7.10.14–44.3
 Control
  Mean ± S.E.28.3  ± 0.4132.3  ± 1.40.6  ± 0.19.0  ± 1.415.2  ± 2.8
  Range27.3–28.931.5–34.30.3–0.9 6.0–12.00.05–8.6 
S-adenosylhomocysteine (nmol/liter)
 Loading
  Mean ± S.E.29.9  ± 3.751.7  ± 7.1** 4.3  ± 0.95.4  ± 0.323.9  ± 4.8
  Range 8.0–56.917.7–97.3 1.2–11.0 4.1–7.22 8.6–73.5
 Control
  Mean ± S.E.28.7  ± 1.832.6  ± 2.40.6  ± 0.14  ± 0.9 1-e
  Range26.0–33.029.1–38.40.1–0.72.0–6.2
Homocysteine (μmol/liter)
 Loading
  Mean ± S.E.8.2  ± 0.56.6  ± 0.5* 1-f −0.3  ± 0.19.6  ± 2.1 1-e
  Range 6.0–11.93.1–8.7−0.01–−0.7  3.0–23.7
 Control
  Mean ± S.E.8.1  ± 0.76.1  ± 0.4−0.3  ± 0.0412.7  ± 5.2 1-e
  Range6.5–9.35.1–6.9−0.2–−0.5 2.0–23.9
Methionine (μmol/liter)
 Loading
  Mean ± S.E.17.7  ± 1.0712.4  ± 0.7* 1-f −0.9  ± 0.16.7  ± 0.4 1-e
  Range13.7–25.2 9.3–16.8−0.1–−1.95–9
 Control
  Mean ± S.E.21.7  ± 1.115.8  ± 3.0−1.2  ± 0.36.7  ± 2.2 1-e
  Range19.5–24.1 8.8–21.3−0.5–−2.0 4–12

  • ↵1-a Baseline concentration.

  • ↵1-b Peak or trough concentration.

  • ↵1-c Weight adjusted difference between Cmax and CO.

  • ↵1-d Weight adjusted AUC above baseline.

  • ↵1-e Not calculated because concentration/time curves were mainly below baseline.

  • ↵1-f Cmax = maximum decrease.