Dose | Administered Dose Present As | |||
---|---|---|---|---|
SMX | N4-Acetyl SMX | SMX-NOH | SMX N1-Glucuronide | |
% | % | % | % | |
SMX (10 mg·kg−1) | 11.5 ± 0.2 | 48.1 ± 7.0 | 1.8 ± 0.7 | <0.5 |
SMX (50 mg·kg−1) | 12.6 ± 2.2 | 49.5 ± 6.0 | 2.4 ± 0.9 | <0.5 |
SMX (250 mg·kg−1) | 13.5 ± 1.5 | 26.0 ± 5.8* | 1.0 ± 0.6 | <0.5 |
↵2-a Animals were administered drug intraperitoneally. Urine was collected for 24 h and analyzed by LC-MS without prior treatment. Values are mean ± SD from four animals. *Statistical analysis was performed by comparing the urinary excretion of the different metabolites at the different doses by the Mann-Whitney test: * P < .05 (comparison of 250 mg·kg−1 against the 10 mg·kg−1 and 50 mg·kg−1 doses).