Table 1

Metabolites of SMX, SMX-NOH and SMX-NO present in male rat bile^1-a

Dose	Administered Dose Present As
Dose	SMX	N₄-Acetyl SMX	SMX-NOH	SMX N₁-Glucuronide	Glutathione Conjugate
	%	%	%	%
SMX (50 mg·kg⁻¹)	1.2 ± 0.3	0.5 ± 0.2	n.d.^1-b	1.4 ± 0.2	n.d.
SMX (250 mg·kg⁻¹)	1.3 ± 0.4	0.4 ± 0.1	n.d.	1.3 ± 0.2	n.d.
SMX-NOH (54 mg·kg⁻¹)	0.8 ± 0.2	0.2 ± 0.1	0.2 ± 0.0	0.7 ± 0.1	n.d.
SMX-NO (54 mg·kg⁻¹)	0.8 ± 0.1	0.1 ± 0.0	n.d.	0.8 ± 0.3	n.d.

↵1-a Anesthetized and cannulated rats were dosed intravenously. Bile was collected for 5 h and analyzed by LC-MS without prior treatment. Values are mean ± SD from four animals.
↵1-b Not detected.