Table 3

Comparison between sheep in renal failure and those with normal kidneys of the individual net clearances of morphine, M3G and M6G by the kidney and their renal excretory clearances during infusion with morphine

Clearance^3-a	Renal failure	Normal^3-b	P
	liter/min
Kidney-morphine	0.22 ± 0.08 (n = 7)^3-c	0.83 ± 0.14 (n = 6)^3-d	<.001
Excretory-morphine	0.0079 ± 0.0051 (n = 6)^3-c	0.067 ± 0.041 (n = 6)^3-d	.006
Kidney-M3G	0.023 ± 0.016 (n = 7)	0.15 ± 0.06 (n = 6)^3-e	<.001
Excretory-M3G	0.015 ± 0.008 (n = 6)	0.19 ± 0.06 (n = 6)^3-e	<.001
Kidney-M6G	0.027 ± 0.024 (n = 7)	0.16 ± 0.05 (n = 5)	<.001
Excretory-M6G	0.016 ± 0.012 (n = 6)	0.16 ± 0.10 (n = 5)	.005

↵3-a Calculated with reference to concentrations in blood.
↵3-b From Milne et al. (1995) supplemented by data from one additional sheep.
↵3-c P = .001.
↵3-d P < .001.
↵3-e P = .045.