Kinetic parameters of COMT activity in rat brain homogenates in the absence and the presence of NE
| Km(μM) | Vmax (nmol mg protein−1h−1) | |
|---|---|---|
| Control | 1.1 (0.5, 1.6) | 1.34 ± 0.04 |
| NE 10 μM | 6.0 (4.3, 7.6)* | 1.39 ± 0.03 |
| NE 30 μM | 15.9 (9.5, 22.3)* | 1.20 ± 0.04 |
Values are arithmetic means ± S.E.M. and geometric means with 95% confidence intervals (n = 4).
* Significantly different from control group (P < .05, Newman-Keuls’ test)