Table 1

Concentration (ng/μl) of E-2078 in CSF and plasma

Time (min)	Subject 3(TO)		Subject 4(SH)		Subject 5(JU)^1-a
Time (min)	CSF	Plasma	Ratio	CSF	Plasma	Ratio	CSF	Plasma	Ratio
0^1-b	N/M^1-c	68	N/M	N/M	88	N/M	N/M	82	N/M
3	0.65	N/M	N/M	N/M	N/M	N/M	1.1	N/M	N/M
5	N/M	30	N/M	N/M	35	N/M	N/M	32	N/M
15	0.48	N/M	N/M	0.44	26	1:58	1.8	19	1:11
30	0.49	N/M	N/M	0.56	21	1:37	1.7	21	1:12
60	1.0	17	1:17	0.45	9.9	1:22	1.2	15	1:12
90	0.46	N/M	N/M	0.43	N/M	N/M	1.1	11	1:10
120	0.40	10	1:26	0.41	11	1:27	0.81	9.3	1:11
180	0.4	9.4	1:21	N/M	8.4	N/M	0.75	6.6	1:9