Protective indices (PI) of the neurosteroids, DZP, PB and MK-801
| Compound | Protective Index (PI = TD50/ED50) | |||
|---|---|---|---|---|
| COCAINE | NMDA (seizures) | NMDA (lethality) | PTZ | |
| 3α,5α-P | 5.6 | N.C.2-a | 5.3 | 11.7 |
| 3α,5β-P | 7.3 | 1.5 | N.C. | 10.0 |
| Ganaxolone | 3.2 | N.C. 2-a | 1.8 | 7.2 |
| Co 2-1068 | 3.9 | 7.0 | 7.8 | 8.4 |
| Pregnenolone | N.C. | N.C. 2-a | N.C. | N.C. |
| DZP | N.C. | 0.2 | 0.8 | 12.0 |
| PB | N.C. | N.C. 2-a | 1.9 | 14.0 |
| MK-801 | 0.5 | 1.3 | 1.3 | N.C. |
↵2-a N.C., Not calculated.