Peak changes in heart rate and MAP induced by microinjection of vehicle, ET-1 or ET-3 into the DVC; the number of rats in each group is given in parentheses
| Parameter | Treatment | Median | 25% | 75% |
|---|---|---|---|---|
| Heart rate | Vehicle (15) | 0 | 0 | 0 |
| ET-1 0.1 pmol (7) | −10 | −10 | −3 | |
| ET-1 1 pmol (6) | −8 | −20 | 0 | |
| ET-1 10 pmol (9) | −10 | −13 | 25 | |
| ET-1 40 pmol (7) | 40 | −28 | 130 | |
| Vehicle (6) | 0 | 0 | 0 | |
| ET-3 1 pmol (3) | 0 | 0 | 0 | |
| ET-3 100 pmol (6) | −3 | −20 | 10 | |
| MAP | Vehicle (16) | 0 | 0 | 0 |
| ET-1 0.1 pmol (7) | 5 | 5 | 9 | |
| ET-1 1 pmol (6) | 5 | 5 | 5 | |
| ET-1 10 pmol (9) | 10* | 8 | 16 | |
| ET-1 40 pmol (7) | 40* | 13 | 64 | |
| Vehicle (8) | 0 | 0 | 0 | |
| ET-3 1 pmol (5) | 0 | 0 | 1 | |
| ET-3 100 pmol (8) | 0 | −5 | 5 |
1-a Statistically significant when compared with corresponding vehicle using Kruskal-Wallis one-way analysis of variance with subsequent Dunn’s test.