Numbers of regenerating myelinated axons and mean axonal areas in the soleus nerve 18 days after sciatic nerve crush
| Saline | FK506 | CSA | |||
|---|---|---|---|---|---|
| 2 mg/kg | 5 mg/kg | 10 mg/kg | 50 mg/kg | ||
| Number of nerves | 9 | 6 | 6 | 5 | 6 |
| Number of myelinated axons | 6 ± 2.02-a | 10 ± 1.1 | 19 ± 3.5* , † | 15 ± 3.7* | 2 ± 1.1 |
| Mean axonal area (μm2) | |||||
| All axons | 0.6 ± 0.02 | 1.1 ± 0.03** | 1.3 ± 0.04** , † | 1.2 ± 0.05** | 0.7 ± 0.03 |
| Largest 30% | 1.6 ± 0.05 | 2.5 ± 0.07* | 3.0 ± 0.09* , † | 2.9 ± 0.10* | 1.8 ± 0.06 |
↵2-a Values are mean ± S.E.M.
* P < .05, compared with saline group (one-way ANOVA followed by FLSD).
** P < .01, compared with saline group (one-way ANOVA followed by FLSD).
† P < .05, compared to 2-mg/kg group (one-way ANOVA followed by FLSD).