Biochemical analysis of mouse serum after treatment with 6TG
| 6TG (mg/kg) Physiol. range | BUN (mg/dl) 10–40 | AST. (u/liter) up to 75 | ALT (u/liter) up to 50 | CK (u/liter) up to 50 | AP (u/liter) up to 100 |
|---|---|---|---|---|---|
| A) Hprt +/+ | |||||
| 0 | 22 ± 5 | 50 ± 9 | 21 ± 6 | 68 ± 17 | 81 ± 15 |
| 25 | 45 ± 25 | 256 ± 74 | 197 ± 67 | 73 ± 14 | 50 ± 33 |
| B) Hprt −/− | |||||
| 0 | 19 ± 1 | 46 ± 6 | 30 ± 12 | 56 ± 26 | 68 ± 33 |
| 25 | 18 ± 1 | 53 ± 18 | 29 ± 15 | 68 ± 41 | 79 ± 23 |
| 500 | 18 ± 1 | 50 ± 12 | 14 ± 4 | 52 ± 23 | 71 ± 38 |
| 720 | 20 ± 3 | 43 ± 14 | 14 ± 2 | 37 ± 11 | 79 ± 21 |
Mice were treated i.p. with single doses of 6TG, control animals were treated with the same volume of sterile distilled wather. The serum samples were taken 14 days after treatment and frozen until analysis. The values represent the averages ± S.D. from three animals. BUN, blood urea nitrogen; AST, aspartate amino transferase; ALT, alanine amino transferase; CK, creatinine kinase; AP, alkaline phosphatase.