In vivo ED50 calculations of various antiinflammatory agents
| Treatment | Time (h) | Leukocyte Infiltration | Fluid PGE2 (COX-2) | Blood PGE2 (COX-1) | Blood/Fluid Selectivity Ratio | Fluid LTB4 | Blood LTB4 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ED50 (mg/kg) | ED50 (mg/kg) | ED50(mg/kg) | ED50 (mg/kg) | ED50 (mg/kg) | ||||||||
| Dexamethasone | 5 | <0.1 | 0.2 | >10 | >50 | 0.3 | NT2-a | |||||
| 24 | 1.99 | 0.08 | >10 | >125 | — | NT2-a | ||||||
| Aspirin | 5 | >300 | <100 | <100 | ∼1 | >300 | >300 | |||||
| 24 | >300 | <100 | <100 | ∼1 | — | >300 | ||||||
| Indomethacin | 5 | <0.1 | <1 | 0.23 | >0.23 | <1 | >10 | |||||
| 24 | 2.1 | <0.1 | 0.67 | >6.7 | — | >10 | ||||||
| Tenidap | 5 | <3 | <10 | 8.92 | >0.89 | >30 | >30 | |||||
| 24 | <3 | ∼6 | >30 | >5 | — | >30 | ||||||
| Nabumetone | 5 | <1 | <1 | >100 | >100 | <3 | NT2-a | |||||
| 24 | >100 | 0.003 | >100 | >100 | — | NT2-a | ||||||
| Nimesulide | 5 | 15.8 | 7.46 | 48.3 | 6.47 | <3 | >100 | |||||
| 24 | >100 | <1 | >100 | >100 | — | >100 | ||||||
| SC-58125 | 5 | 0.4 | 17.3 | >30 | >1.73 | 0.8 | NT2-a | |||||
| 24 | 50.8 | <3 | >30 | >10 | — | NT2-a | ||||||
| RWJ 63556 | 5 | <0.01 | >10 | 35.9 | <3.6 | <0.01 | 4.43 | |||||
| 24 | 0.9 | 3 | 45.5 | 15.2 | — | >10 | ||||||
| Zileuton | 5 | <1 | >100 | ∼100 | NA2-b | <1 | 0.6 | |||||
| 24 | <1 | ∼1 | >100 | NA2-b | — | >10 | ||||||