Transport of clonidine across brain capillary endothelial cells
| Direction of transport | Glucose | Papp of sucrose1-a | Ratio of Papp values1-a (clonidine/sucrose) |
|---|---|---|---|
| mM | ×10−3 cm/min | ||
| Apical to basolateral | 4 | 3.50 ± 0.12 | 1.29 ± 0.02b |
| Basolateral to apical | 4 | 3.22 ± 0.24 | 1.27 ± 0.03b |
| Apical to basolateral | 20 | 5.62 ± 1.30 | 1.04 ± 0.02c |
| Basolateral to apical | 20 | 6.25 ± 0.77 | 1.03 ± 0.02c |
↵1-a Values are mean ± S.E.M. of 3 experiments.
b, c Difference between ratios was considered nonsignificant by two-tailed Student’s t test (P > .05).