Table 3

Pharmacological characterization of [3H]NGD 94-1 binding in hippocampal membranes from rat and human brain tissue3-a

Ki
RatHuman
nm
Clozapine19.4  ± 10.635.2  ± 6.8
Eticlopride10.8  ± 0.913.9  ± 6.2
Octoclothepin13.6  ± 7.212.7  ± 0.2
Spiperone4.8  ± 0.27.6  ± 6.6
(−)-Sulpiride>2000>2000
Raclopride>2000>2000
  • 3-a Data represented as mean ± S.E.M. from three separate subjects.