Behavioral profiles of NRA0045: comparison with clozapine, haloperidol and chlorpromazine
| Route | ED50 (mg/kg) | ||||
|---|---|---|---|---|---|
| NRA0045 | Clozapine | Haloperidol | Chlorpromazine | ||
| Spontaneous locomotor activity (mouse) | i.p. | 0.9 | 3.0 | 0.3 | 1.5 |
| MAP-induced locomotor hyperactivity (mouse) | i.p. | 0.5 | 1.0 | 0.2 | 0.6 |
| MAP-induced locomotor hyperactivity (mouse) | p.o. | 1.9 | 2.7 | 0.5 | 2.2 |
| MAP-induced stereotyped behavior (mouse) | i.p. | >30 | >30 | 0.1 | 3.5 |
| Induction of catalepsy (rat) | i.p. | >30 | >30 | 0.2 | 1.4 |
| Tryptamine-induced seizure (rat) | i.p. | 1.5 | 2.4 | 1.1 | 2.1 |
| NE-induced lethality (rat) | i.p. | 0.2 | 2.6 | 3.2 | 0.6 |