Affinities of NRA0045 and dopamine receptor antagonists for the human cloned dopamine D2 family
| Compound | hD2L | hD3 | hD4.2 |
|---|---|---|---|
| Ki (nM) | |||
| NRA0045 | 231.90 ± 51.58 | 107.49 ± 2.07 | 2.54 ± 0.78 |
| Clozapine | 546.60 ± 216.6 | 84.07 ± 21.21 | 72.06 ± 9.30 |
| Haloperidol | 9.90 ± 0.87 | 1.50 ± 0.23 | 8.63 ± 0.99 |
| Chlorpromazine | 13.61 ± 4.12 | 1.56 ± 0.57 | 66.80 ± 10.29 |
Values are mean ± S.E.M. of three to nine separate experiments, each done in duplicate.