Table 2

Competition studies of different compounds with ligands of monoamine transporters: [3H]GBR 12935 (DA transporter), [3H]paroxetine (5-HT transporter), and [3H]nisoxetine (NE transporter)

Ki
[3H]GBR 12935[3H]Paroxetine[3H]Nisoxetine
nM
β-CDIT29  ± 550  ± 6500  ± 120
β-CIT27.5  ± 43.1  ± 0.280  ± 28
GBR 129351.6  ± 0.5
Mazindol12  ± 38  ± 1.5
Paroxetine0.8  ± 0.3
Nisoxetine3.4  ± 0.9
Desipramine40  ± 8
  • K i values were calculated from IC50values according to the method of Cheng and Prussoff (1973):K i = IC50/(1 + L * /K d). Results are mean ± S.D. of three independent experiments.