Table 3

Interaction of lobeline and nicotine in different pharmacological tests after s.c. administration in mice (effects on body temperature and locomotor activity)

Pretreatment Dose^3-a	Challenge Dose^3-a	Response
Pretreatment Dose^3-a	Body Temperature^3-b	Δt°C (mean ± S.E.)
Saline	Saline	−0.3 ± 0.2
Saline	Nicotine (0.25)	−0.6 ± 0.1
Lobeline (1)	Saline	−1.0 ± 0.1
Lobeline (1)	Nicotine (0.25)	−1.0 ± 0.1

	Locomotor activity^3-c	No. of interruptions (mean ± S.E.)

Saline	Saline	1625 ± 194
Saline	Nicotine (0.1)	1547 ± 71
Lobeline (1)	Saline	1300 ± 130
Lobeline (1)	Nicotine (0.1)	1854 ± 248

↵3-a Doses are expressed in mg/kg in parentheses.
↵3-b Mice were challenged with nicotine 20 min after lobeline pretreatment.
↵3-c Mice were challenged with nicotine 10 min after lobeline pretreatment.