Phase | ED501-a |
---|---|
Base line | 2.9 ± 0.8 |
Single-dosing phase | |
First determination | 4.2 ± 1.1 |
Second determination | 3.4 ± 1.0 |
Third determination | 5.1 ± 2.9 |
Fourth determination | 2.8 ± 0.8 |
Fifth determination | 2.4 ± 0.4 |
Sixth determination | 2.8 ± 0.5 |
Seventh determination | 2.3 ± 1.0 |
Double-dosing phase | 1.5 ± 0.5 |
Abstinence | 5.5 ± 3.0 |
↵1-a Values given are group means ± S.E. in milligrams per kilogram and were determined from linear regression of individual morphine dose-response curves.