n | Lesion Intensity | Mean Lesion Number ± S.E. | |||||
---|---|---|---|---|---|---|---|
+/− | + | ++ | +++ | ++++ | |||
Prophylactic | |||||||
Vehicle | 10 | 0 | 4 | 2 | 2 | 2 | 69 ± 10 |
0.15 mg MK-801 | 6 | 0 | 2 | 1 | 3 | 0 | 61 ± 15 |
0.3 mg MK-801 | 6* | 4 | 1 | 0 | 1 | 0 | 27 ± 19** |
Therapeutic | |||||||
Vehicle | 5 | 0 | 2 | 2 | 1 | 0 | 43 ± 8 |
0.3 mg MK-801 | 6 | 0 | 3 | 2 | 1 | 0 | 40 ± 9 |
0.6 mg MK-801 | 5 | 0 | 2 | 2 | 1 | 0 | 51 ± 14 |
Mann-Whitney U test analysis of data showed significant differences from vehicle controls of * P < .02 for lesion severity and ** P < .05 for lesion number.