Table 2

Incubation of 14C PHT with human liver slices

HL IDK-H Buffer4% BSA in K-H Buffer
Vmax2-aKm2-bVmaxKm
2123.07.9591.92.03
22175.3.68170.1.44
2339.410.536.02.58
24148.4.44181.2.74
Mean96.46.64120.2.20
S.D.76.33.1768.50.59
Coefficient of variation, %79.247.857.226.8
  • 2-a Vmax results expressed as pmol/min/g liver tissue.

  • 2-b All K m values are expressed as μM unbound PHT.