Comparison of parameters for [3H]DA release and membrane binding for nine agonists
| Inhibition of l-NIC binding (KI) | Inhibition of αBTX binding (KI) | |
|---|---|---|
| Activation of transient release (K T) | S = 0.93 | S = 0.80 |
| R = 0.97 | R = 0.82 | |
| Activation of persistent release (K P) | S = 1.05 | S = 0.94 |
| R = 0.98 | R = 0.87 | |
| Inhibition of transient release (K IA) | S = 1.00 | S = 0.89 |
| R = 0.98 | R = 0.86 | |
| Inhibition of l-NIC binding (K I) | S = 0.87 | |
| R = 0.85 |
S = slope; R = correlation coefficient.K T and K P values are from table2; K IA values are from fig. 7. K Ivalues for inhibition of [3H]l-NIC binding are from Marks et al. (1996). K I values for inhibition of [125I]αBTX binding are from unpublished data (Marks, M.J.).