First modulator | Dose ratio4-a (DR1) | Second modulator | Dose ratio4-a (DR2) | Experimental combination dose ratio4-a (DR3) | Predicted range for combination dose ratios of ternary complex4-b |
---|---|---|---|---|---|
μM | μM | ||||
C7/3′-phth | 321 | Gallamine | 40 | 310 | |
(30) | (270–381; 4) | (100) | (24–65; 4) | (267–360; 4) | 287–310 |
C7/3′-phth | 256 | Gallamine | 18 | 186 | |
(30) | (219, 299; 2) | (30) | (14–20; 9) | (164, 212; 2) | 250–253 |
Gallamine | 18 | C7/3′-phth | 298 | 185 | |
(30) | (13–25; 5) | (30) | (248–358; 6) | (135–256; 6) | 244–348 |
Gallamine | 40 | C7/3′-phth | 112 | 95 | |
(100) | (24–65; 4) | (10) | (81–135; 5) | (70–127; 4) | 102–145 |
↵4-a See tables 1 and 2.
↵4-b Predicted range of combination dose ratios for the ternary complex obtained using equation 15; the range was calculated using the 95% confidence limits of the second modulator listed under DR2. None of the experimental combination geometric mean dose ratios differed significantly from the lower predicted range value (P < .05).