Benzodiazepine, GABA, barbiturate and neurosteroid effects on ultrasonic vocalizations in 7-day rat pups
| Treatment | ED50 (mg/kg) | 95% C.I. (mg/kg) |
|---|---|---|
| Allopregnanolone | 4.55 | 3.19, 6.49 |
| + Flumazenil (0.1 mg/kg) | 4.11 | 2.51, 6.72 |
| + Bicuculline (1 mg/kg) | 4.57 | 3.18, 6.57 |
| + Picrotoxin (1 mg/kg) | 6.93 | 4.77, 10.08 |
| Alprazolam | 0.08 | 0.04, 0.17 |
| + Flumazenil (0.1 mg/kg) | 0.591-a | 0.26, 1.33 |
| + Allopregnanolone (3 mg/kg) | 0.02 | 0.01, 0.08 |
| Diazepam | 0.34 | 0.16, 0.74 |
| + Flumazenil (0.1 mg/kg) | 3.561-a | 2.57, 4.91 |
| + Allopregnanolone (3 mg/kg) | 0.051-a | 0.02, 0.09 |
| Muscimol | 0.08 | 0.05, 0.13 |
| + Bicuculline (1 mg/kg) | 0.281-a | 0.15, 0.55 |
| + Allopregnanolone (3 mg/kg) | 0.47 | 0.07, 3.12 |
| Pentobarbital | 6.59 | 5.92, 7.75 |
| + Picrotoxin (1 mg/kg) | 10.31 | 7.51, 14.15 |
| + Allopregnanolone (3 mg/kg) | 3.661-a | 1.70, 5.89 |
↵1-a Indicates significant differences from the tested agonist.