Correlation matrix between DTZ N-demethylation and other microsomal oxidations mediated by human CYPs
| r | |||||
|---|---|---|---|---|---|
| Testosterone 6β-hydroxylation | Aniline 4-hydroxylation | 7-Ethylresorufin O-deethylation | Dimethylnitrosamine N-demethylation | Tolbutamide hydroxylation | |
| DTZ N-demethylation | 0.82a | 0.23 | 0.10 | 0.17 | 0.59c |
| Testosterone 6β-hydroxylation | 0.02 | 0.01 | 0.12 | 0.61b | |
| Aniline 4-hydroxylation | 0.20 | 0.72b | 0.65c | ||
| 7-Ethylresorufin O-deethylation | 0.12 | 0.05 | |||
| Dimethylnitrosamine N-demethylation | 0.46 | ||||
Correlation coefficient significant: a P < .001,b P < .01, c P < .05.