Table 1

Effect of mannitol in ischemic mice1-a

Dose (g/kg)
12
a. Brain water content (%)
 C
  Sham-op.78.30  ± 0.0878.73  ± 0.16
  Controls84.00  ± 0.4584.49  ± 0.55
  Mannitol84.73  ± 0.5883.77  ± 0.37
 P
  Sham-op.79.41  ± 0.0879.50  ± 0.15
  Controls81.12  ± 0.2581.22  ± 0.22
  Mannitol81.79  ± 0.3981.13  ± 0.48
b. Serum osmolality (mOsm/kg)
  Sham-op.320.1  ± 1.3316.2  ± 1.3
  Controls314.5  ± 1.2312.8  ± 1.3
  Mannitol318.4  ± 1.1* 323.0  ± 1.1***
  • 1-a Mannitol was administered i.p. 23 h after onset of ischemia and measurements made at time 24 h. Brain water was measured at 24 h in the core (C) and the periphery (P) of the ischemic tissue. Mean ± SEM of 11 to 14 animals per group. Mann-Whitney U test vs. ischemia controls: * P < .05; *** P < .001.