Summary of drug actions in tests of potential anxiolytic and antiaggressive activity as compared with motor disruption
| Hippocampal 5-HT | Geller Conflict | Pigeon Conflict | (+)-Maze | USV | Aggression | LRR | Ataxia Mice | FBP | Spontaneous Locomotion | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | Duration | Mice | Rats | |||||||||
| Injection route | s.c. | s.c. | i.m. | s.c. | s.c. | s.c. | s.c. | s.c. | s.c. | s.c. | s.c. | s.c. |
| S 15535 | 0.1 | 0.3 | 0.04 | >10.0 | 0.63 | 1.25 | 2.5 | >40.0 | 40.0 | >40.0 | 40.0 | 40.0 |
| Buspirone | N.T. | N.T. | 0.31 | >40.0 | 0.31 | 2.5 | 2.5 | >40.0 | 2.5 | 0.5 | 2.5 | 2.5 |
| WAY 100,635 | N.T. | N.T. | >0.16 | >0.63 | >0.63 | >0.63 | >0.63 | >0.63 | >0.63 | >0.63 | >0.63 | >0.63 |
| Diazepam | N.T. | 1.25** | 10.0 | 0.16 | 10.0 | >10.0 | 10.0 | 2.5 | 0.63 | N.T. | N.T. | N.T. |
Doses are Minimal Effective Dose (P < .05 to vehicle) with the exception of LRR and FBP, where they are ED50 values. Doses are in milligrams per kilogram. * The s.c. route cannot be performed in pigeons. ** i.p. route. LRR = loss of righting reflex; N.T. = not tested; FBP = flat body posture, a component of the serotonin syndrome mediated by postsynaptic 5-HT1A receptors (data from Millan et al., 1992b,1994).