Effect of variabilin on zymosan-injected mouse air pouch
| Cell Accumulation (× 106/ml) | PGE2 (ng/ml) | LTB4 (ng/ml) | |
|---|---|---|---|
| Saline | 1.1 ± 0.2 | 2.3 ± 0.7 | 1.4 ± 0.3 |
| Zymosan | 16.5 ± 1.3 | 63.6 ± 4.9 | 37.5 ± 4.1 |
| Variabilin | |||
| 0.001 (μmol/pouch) | 17.6 ± 2.6 | 46.3 ± 5.9 | 26.4 ± 5.3 |
| 0.01 (μmol/pouch) | 15.3 ± 3.0 | 42.7 ± 5.9* | 22.2 ± 3.7* |
| 0.1 (μmol/pouch) | 18.9 ± 3.1 | 31.5 ± 4.5** | 16.7 ± 2.6** |
| 1 (μmol/pouch) | 11.7 ± 1.4 | 23.6 ± 1.9** | 13.4 ± 1.3** |
| Indomethacin | |||
| (0.1 μmol/pouch) | 13.6 ± 1.0 | 2.0 ± 0.4** | 44.7 ± 2.8 |
| ZM230,487 | |||
| (0.1 μmol/pouch) | 11.0 ± 0.8* | 59.2 ± 6.0 | 4.3 ± 1.2** |
Data are mean ± S.E.M. from 6 to 12 animals. * P < .05;** P < .01.