The effects of DEX and KCZ on aortic CYP activities
| Metabolite (nmol/mg prot/min) | ||
|---|---|---|
| 6β-OHT | 2α-OHT | |
| Control | N.M. | N.M. |
| DEX-treated | 0.145 ± 0.036* | 0.057 ± 0.041 |
| DEX- and KCZ-treated | 0.042 ± 0.037 | 0.047 ± 0.039 |
Each data point is the mean ± S.D. of three different sample pools, subject to the same pretreatment, with some samples taken from the same tissues that underwent cGMP analysis. 6β-OHT (6β testosterone hydrolase activity) and 2α-OHT (2α testosterone hydrolase activity) are the markers for CYP3A and CYP2C activities, respectively.
* P < .05 compared with DEX- and KCZ-treated rats, one-way ANOVA followed by Newman-Keuls test. N.M.: not measurable.