Time after bolus dose (hr) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
0 | 0.33 | 0.67 | 1 | 2 | 3.5 | 5 | 7 | 9 | 12 | |
CSa b | ||||||||||
Young | 1.42 | 0.73 | 0.91 | 0.91 | 0.97 | 1.04 | 1.11 | 1.16 | 1.25 | 1.27 |
(0.3) | (0.4) | (0.3) | (0.3) | (0.3) | (0.3) | (0.3) | (0.3) | (0.3) | (0.3) | |
Elderly | 1.26 | 0.07 | 0.31 | 0.54 | 0.71 | 0.77 | 0.86 | 0.89 | 0.98 | 1.09 |
(0.1) | (0.2) | (0.3) | (0.3) | (0.2) | (0.2) | (0.2) | (0.2) | (0.2) | (0.2) | |
Continuous performance testa c | ||||||||||
Young | 357.7 | 640.5 | 566.4 | 631.4 | 501.3 | 403.9 | 409.3 | 382.3 | 374.1 | 345.8 |
(24.6) | (270.6) | (163.2) | (210.3) | (158.0) | (48.6) | (61.3) | (46.7) | (48.5) | (30.2) | |
Elderly | 407.8 | 1378.3 | 1143.6 | 961.5 | 631.7 | 571.4 | 517.2 | 479.5 | 488.0 | 405.2 |
(45.3) | (169.8) | (379.9) | (303.4) | (186.6) | (180.3) | (84.0) | (61.3) | (143.6) | (26.0) | |
NRSSc d | ||||||||||
Young | 0 | 3 | 2 | 2 | 3 | 3 | 2.5 | 2 | 1 | 0 |
(0–1) | (1–4) | (0–4) | (1–4) | (1–4) | (1–3) | (0–4) | (0–3) | (0–3) | (0–1) | |
Elderly | 0 | 4 | 4 | 3 | 3 | 3 | 3 | 3 | 2 | 3 |
(0–0) | (2–4) | (1–4) | (1–4) | (1–4) | (1–3) | (0–3) | (0–3) | (0–3) | (0–3) | |
RMTb d | ||||||||||
Young | 7 | —2-e | 3 | —2-e | 5 | 5 | —2-e | 5 | 7 | —2-e |
(6–7) | (0–7) | (0–7) | (2–7) | (2–7) | (5–7) | |||||
Elderly | 7 | —2-e | 0 | —2-e | 2.5 | 5 | —2-e | 5.5 | 6 | —2-e |
(6–7) | (0–5) | (0–7) | (0–6) | (3–7) | (4–7) |
2-a Data are presented as mean (S.D.).
2-b The lower the score, the greater is the decrement.
2-c The higher the score, the greater is the decrement or sedation.
2-d Data are presented as median (range).
↵2-e Memory was not assessed at this interval.