Table 1

PGE2 and prostacyclin (measured as 6-keto-PGF) production by rat colon in response to H2O2 (5 × 10−4 M) and effect of PAF antagonists and 1 μM INDO

Agonist + antagonistPGE26-Keto-PGF
Control4.5  ± 1.840.8  ± 4.8
 +INDO0.2  ± 0.21-b 4.1  ± 1.81-b
+WEB 2086 (10−4 M)2.4  ± 1.639.0  ± 3.7
 +INDO0.2  ± 0.71-b 7.0  ± 2.41-b
BN 52021 (10−4 M)3.0  ± 1.628.0  ± 2.7
 +INDO0.3  ± 0.71-b 7.8  ± 2.7
Ro 24-0238 (10−5 M)0.5  ± 0.71-a 9.2  ± 2.41-a
 +INDO−1.0  ± 0.41-b 3.7  ± 1.61-b
Ro 24-4736 (10−6 M)4.2  ± 0.243.2  ± 2.8
 +INDO0.1  ± 0.31-b 5.4  ± 1.01-b

PG production rate (ng/15 min/cm2) in the serosal solution of Ussing-chambered rat colon measured 30 min before and 30 min after the addition of H2O2.

  • 1-a P < .05 control vs. PAF antagonists.

  • 1-b P < .05 control vs. PAF antagonist + INDO.

  • n = 4.