Ligand | Ki | ||
---|---|---|---|
hNK-3 | hNK-2 | hNK-1 | |
nm | |||
NKB | 0.81 ± 0.21 | 16.5 ± 1.5 | 554 ± 157 |
NKA | 539 ± 51 | 0.74 ± 0.16 | 647 ± 177 |
Substance P | 1,292 ± 232 | 129 ± 5 | 2.8 ± 1.3 |
[MePhe7]NKB | 0.31 ± 0.05 | 1,597 ± 202 | >10,000 |
Senktide | 2.85 ± 0.43 | >10,000 | >10,000 |
SB 223412 | 1.0 ± 0.1 | 144 ± 22 | >100,000 |
SR 142801 | 1.2 ± 0.2 | 40 ± 6 | 744 ± 313 |
SR 48968 | 707 ± 144 | 0.23 ± 0.04 | 454 ± 76 |
CP 99994 | >10,000 | 17,000 ± 1,041 | 0.42 ± 0.05 |
K i values (mean ± S.E.M.) are obtained from 3 to 10 independent experiments performed in duplicate. Membranes for the assays are from CHO cells stably expressing individually the hNK-3, hNK-2 or hNK-1 receptor.