Correlation between the potencies of alpha-1 AR antagonists against NE-induced responses in urogenital models (isolated rabbit prostate and urethra or UP in the anesthetized dogs) or binding affinity in dog prostate. The correlation with their functional affinity for the alpha-1L AR subtype (rabbit aorta after CEC) is also reported in the table.
| Alpha-1L Subtype | Rabbit Urethra | Rabbit Prostate | Dog Prostate | Dog UP | |
|---|---|---|---|---|---|
| Alpha-1L subtype | – | .8591 | .6616 | .7248 | .6256 |
| Rabbit urethra | – | – | .6755 | .7527 | .7830 |
| Rabbit prostate | – | – | – | .6440 | .4780 |
| Dog prostate | – | – | – | – | .6629 |
Data represent the R2 values.