Cumulative urinary excretion of the enantiomers of the gallopamil metabolites and the total urinary recovery of each enantiomer (parent drug plus metabolites) in six healthy subjects after administration of 50 mg of pseudoracemic gallopamil HCl (i.e., 47.9 μmol of each enantiomer)
| Subject | Substance | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D832 | D845 | D829 | PR53 | SZ488 | Total recovery | |||||||
| (S) | (R) | (S) | (R) | (S) | (R) | (S) | (R) | (S) | (R) | (S) | (R) | |
| [μmol] | ||||||||||||
| 1 | 6.2 | 9.3 | 0.44 | 0.23 | 1.10 | 0.83 | 0.27 | 0.03 | 0.27 | 0.02 | 8.54 | 10.59 |
| 2 | 4.8 | 6.8 | 0.38 | 0.15 | 1.06 | 0.73 | 0.20 | 0.02 | 0.25 | 0.02 | 6.79 | 7.75 |
| 3 | 5.9 | 8.0 | 0.34 | 0.22 | 1.03 | 0.75 | 0.19 | 0.03 | 0.19 | 0.02 | 7.81 | 9.15 |
| 4 | 3.6 | 5.4 | 0.51 | 0.31 | 0.65 | 0.63 | 0.17 | 0.03 | 0.20 | 0.03 | 5.62 | 6.79 |
| 5 | 3.8 | 6.4 | 0.37 | 0.17 | 0.66 | 0.49 | 0.16 | 0.02 | 0.20 | 0.02 | 5.58 | 7.29 |
| 6 | 5.1 | 8.1 | 0.41 | 0.16 | 1.10 | 0.60 | 0.42 | 0.03 | 0.42 | 0.03 | 7.63 | 8.98 |
| Mean | 4.9 | 7.3 | 0.41 | 0.21 | 0.93 | 0.67 | 0.23 | 0.03 | 0.25 | 0.02 | 6.99 | 8.43 |
| S.D. | 1.1 | 1.4 | 0.06 | 0.06 | 0.22 | 0.12 | 0.10 | 0.01 | 0.09 | 0.01 | 1.22 | 1.41 |
| Mean S/Rratio | 0.66 | 2.14 | 1.38 | 9.15 | 11.26 | 0.83 | ||||||
| S.D. | 0.05 | 0.58 | 0.24 | 3.61 | 3.11 | 0.04 | ||||||
The ratios (mean ± S.D.) of the (S)- to (R)-enantiomers in all subjects for each analyte are also given.