Table 3

Pharmacokinetic parameters of (R)-gallopamil HCl after the 100-mg dose

Subject	C_max	t_max	t_1/2	AUC	CL_o	F	A_e	MRT	CL_R	f_u
	nmol/liter	hr		hr·nmol/liter	liter/min	%	nmol	hr	ml/min
1	103.3	0.50	7.7	187.4	4.3	23.5	251.8	2.8	22.4	0.045
2	51.2	1.50	5.2	151.2	21.2	5.2	242.0	4.2	26.7	0.057
3	156.7	1.50	3.7	339.7	9.4	11.4	659.7	4.0	32.4	0.045
4	380.6	0.75	N.D.	1295.3^3-b	2.5	37.8	1465.3	6.2	18.9	0.044
5	364.5	0.50	4.5	531.5	6.0	17.4	1141.3	3.0	35.8	0.030
6	438.2	0.75	5.2	943.8	3.4	29.0	1260.7	3.7	22.3	0.049
Mean	249.1^3-a	0.92	5.0^3-c	574.8^3-a	7.8	20.7	836.8^3-a	4.0	26.4	0.045
S.D.	164.5	0.47		456.5	7.0	11.9	528.2	1.2	6.5	0.009

↵3-a P < .05: 25 mg vs. 100 mg.
↵3-b AUC(0–25 hr): in other subjects, <5% of total AUC results from extrapolation to infinity.
↵3-c Harmonic mean.
N.D. = not determined.