Mean (±S.D.) PK parameters for alprazolam and mean (± S.D.) AUC(0–6 h) values for caffeine and its three DMX metabolites after i.v. 1.25 mg/kg alprazolam ± i.v. 10 mg/kg; mean (±S.D.) PK parameters for caffeine after i.v. 10 mg/kg caffeine dose
| Alp | Alp + Caff | Caffeine | |
|---|---|---|---|
| Vc(liter/kg) | 1.68 | 1.18 | 0.89 |
| (0.26) | (0.41) | (0.17) | |
| Cl (liter/hr/kg) | 6.90 | 6.00 | 0.29 |
| (0.99) | (0.63) | (0.06) | |
| Vss(liter/kg) | 3.22 | 2.23 | |
| (0.32) | (0.38) | ||
| α (min−1) | 0.165 | 0.20 | |
| (0.03) | (0.06) | ||
| t 1/2 α (min) | 4.64 | 4.21 | |
| (0.76) | (1.33) | ||
| β (min−1) | 0.025 | 0.03 | 0.005 |
| (0.00) | (0.00) | (0.00) | |
| t 1/2 β(min) | 27.85 | 24.83 | 187.06 |
| (1.76) | (1.23) | (57.35) | |
| AUC(0–∞) (μg × min/ml) | 11.52 | 12.78 | 2315.31 |
| (1.26) | (1.15) | (524.30) | |
| i.v. 10 mg/kg Caffeine | i.v. 10 mg/kg Caffeine + i.v. 1.25 mg/kg alprazolam | |||||||
|---|---|---|---|---|---|---|---|---|
| Caff | Theob | Para | Theop | Caff | Theob | Para | Theop | |
| AUC(0–6 hr) (μg × min/ml) | 2184.80 | 71.01 | 99.61 | 74.18 | 2249.30 | 73.64 | 103.02 | 75.52 |
| (162.69) | (5.84) | (14.36) | (7.83) | (130.05) | (7.10) | (14.53) | (9.15) | |
AUC(0–6 h) values for caffeine and its three DMXs in the presence and absence of alprazolam