Compound | IC50 | Maximum Protection | Potential Required to Oxidize 50% of Test Compound |
---|---|---|---|
μM | % control | mV | |
U-74006F | 25.4 | 60.5 | 540 |
U-87663E | 1.3 | 100 | 530 |
U-89843E | 7.0 | 83.4 | 423 |
U-94430E | 0.3 | 75.8 | 369 |
U-101033E | 1.1 | 75.8 | 408 |
U-104067E | 10.6 | 80.6 | 894 |
U-106311E | 4.5 | 100 | 125 |
Cultures were pretreated with test compound in varying concentrations for 1 hr. The medium containing the compound was then removed, and the treated cultures were exposed to 200 μM ferrous ammonium sulfate for 1 hr, followed by determination of 3H-AIB uptake. Potentials required to oxidize 50% of the test compound were determined as described under “Methods.”