Table 1

The rates of formation of the cysteine conjugate and protein adducts catalyzed by microsomes from human, lymphoblasts transfected with the cDNAs for various human CYPs

CYP Form	Concentration^1-a	Cysteine Conjugation^1-a		Protein Binding^1-a
	pmol P450/mg prot	nmol/min-mg prot	pmol/min-pmol P450	pmol min-mg prot	fmol/min-pmol P450
None	0	0^1-b	0	0	0
1A1	34	0	0	0	0
1A2	132	0	0	1.06 ± 0.17^1-c	8.0 ± 1.3
2A6	135	0	0	0	0
2B6	190	0	0	0	0
2D6	248	1.45 ± 0.05	5.85 ± 0.20	0	0
2E1	124	1.27 ± 0.02	10.24 ± 0.16	12.20 ± 0.28^1-d	98.4 ± 2.3
3A4	62	0	0	0.54 ± 0.09^b,c	8.7 ± 1.5

↵1-a prot, protein.
↵1-b Values are the average ± S.E.M. of duplicate incubations.
↵1-c P < .05 from control.
↵1-d P < .001 from control.