The enhancing effects of both amastatin and phosphoramidon and the negative effect of captopril on the inhibitory potency of met-enk-RGL in guinea pig ileum
| Inhibitor | IC50(nM) | Ratio of potency | % Difference |
|---|---|---|---|
| None | 616 ± 110 | 1 | |
| 72.9 ± 1.8*** | |||
| Amastatin | 171 ± 40 | 3.74 ± 0.25 | |
| None | 750 ± 110 | 1 | |
| 29.2 ± 2.7*** | |||
| Phosphoramidon | 522 ± 63 | 1.42 ± 0.053 | |
| None | 411 ± 110 | 1 | |
| 0.936 ± 0.11 | |||
| Captopril | 414 ± 120 | 0.985 ± 0.073 |
Each PI at the final concentration of 1 μM was given 10 min before the octapeptide administration.
Each value represents the mean ± S.E. of four experiments.
*** P < .01