Peak plasma concentration of ISIS 2302 after various dose regimens
| Dose | Intravenous Infusion Duration | Cmax1-a |
|---|---|---|
| mg/kg | min | μg/ml |
| 20 | 10 | 274 ± 102 |
| 10 | 10 | 146 ± 43 |
| 10 | 30 | 108 ± 40 |
| 10 | 60 | 75 ± 9.5 |
| 6.6 | 60 | 64 ± 10 |
| 6 | 120 | 30 ± 7 |
| 3.3 | 60 | 35 ± 6.4 |
| 2 | 2 | 40 ± 9.7 |
↵1-a Values represent mean ± S.D. of plasma ISIS 2302 concentrations determined at the end of infusion.