Lipid-lowering effect of RPR 107393, lovastatin and pravastatin in male marmosets
| Study | Treatment | Dose | Cholesterol | Triglycerides | n |
|---|---|---|---|---|---|
| mg/kg | mg/dl | ||||
| 1 | Control | 0 | 180 ± 8 | 10 | |
| Lovastatin | 50 | 129 ± 5 (−28%)5-a | 10 | ||
| 2 | Control | 0 | 155 ± 4 | 8 | |
| Pravastatin | 50 | 107 ± 8 (−31%)5-a | 8 | ||
| 3 | Control | 0 | 177 ± 14 | 37 ± 6 | 8 |
| RPR 107393 | 20 | 88 ± 8 (−50%)5-a | 23 ± 25 (−37%)5-a | 8 | |
| Lovastatin | 10 | 135 ± 7 (−24%)5-a | 32 ± 2 (−13%)5-a | 8 | |
Drugs were given p.o. b.i.d. for 7 days to male marmosets. Results are presented as mean ± S.E.M. Percent changes from respective control values are given in parentheses.
↵5-a P < .05 compared with control values.