Table 5

Hemodynamic effects of nifedipine (0.05 mg/ml) in rats before (T0) and 1 hr after (T60) a 1-hr single-pass mode cefixime (0.5 mg/ml) intestinal perfusion at pH 5.5

Cefixime group (n = 6)Nifedipine + cefixime group (n = 7)
T0T60T60
mm Hg
Mean arterial pressure82.2  ± 3.056.5  ± 5.65-a 51.4  ± 4.0
ml/min/g tissue wt
Organ blood flow
 Intestine0.62  ± 0.0060.26  ± 0.095-a 0.44  ± 0.12
 Mesentery-pancreas0.36  ± 0.040.17  ± 0.065-a 0.22  ± 0.06
 Liver0.50  ± 0.060.21  ± 0.055-a 0.21  ± 0.04
 Heart10.3  ± 0.878.32  ± 2.207.31  ± 1.37
ml/min/100 g body wt
Portal tributary blood flow2.52  ± 0.291.14  ± 0.425-a 1.74  ± 0.4
ml/min/100 g body wt
Splanchnic tributary blood flow4.00  ± 0.421.76  ± 0.545-a 2.35  ± 0.51
  • Values are mean ± S.E.M.

  • 5-a P < .05, T60 vs. T0.