Effect of nifedipine on salicylic acid absorption
| Time | ||||||||
|---|---|---|---|---|---|---|---|---|
| 15 | 20 | 25 | 30 | 35 | 40 | 45 | 50 | |
| min | ||||||||
| Residual % of salicylic acid (% of total) | ||||||||
| Control | 85.1 ± 5.6 | 84.5 ± 1.3 | 78.2 ± 2.1 | 74.7 ± 2.4 | 68.3 ± 2.0 | 63.9 ± 1.8 | 60.8 ± 2.4 | 57.1 ± 2.8 |
| + Nifedipine | 87.4 ± 1.4 | 80.3 ± 1.23-a | 76.8 ± 0.9 | 66.2 ± 1.93-a | 64.0 ± 2.2 | 59.1 ± 2.6 | 55.6 ± 2.1 | 52.8 ± 1.6 |
Salicylic acid 0.4 mg/ml with 1.85 KBq/ml [7-14C]salicylic acid was driven by a recirculating procedure after a 15-min nifedipine (nifedipine) or its adjuvent (control) perfusion.
↵3-a P < .05, difference between percentages.