Effect of 15 days of once daily oral dosing, L-738,167, 30 μg/kg, on platelet sensitivity to ADP in conscious dogs
| Extent of ADP-Induced Aggregation ED50 (μM) | Rate of ADP-Induced Aggregation ED50 (μM) | |
|---|---|---|
| Baseline | 10.4 ± 2.9 | 4.9 ± 0.72 |
| Day 11 during dosing | >100 | >100 |
| 9 days postdosing | 12.3 ± 4.0 | 5.2 ± 1.2 |
| 15 days postdosing | 8.0 ± 1.8 | 2.7 ± 0.89 |
| 23 days postdosing | 11.7 ± 4.1 | 3.9 ± 0.83 |
Data are mean ± S.E.M., n = 5. Postdosing determinations were made 9, 15 and 23 days after the final day of oral dosing.