Effect of EEDQ on the basal discharge of LC neurons1-a
| Pretreatment | Firing Rate (Hz) | Variation Coefficient (%) | Burst Firing (%) | n |
|---|---|---|---|---|
| Control | 1.83 ± 0.34 | 43.5 ± 4.1 | 1.46 ± 0.67 | 9 |
| EEDQ | ||||
| 1 mg/kg | 2.78 ± 0.53 | 48.1 ± 3.0 | 4.31 ± 1.77 | 5 |
| 2 mg/kg | 3.04 ± 0.35 | 47.6 ± 2.1 | 2.93 ± 1.34 | 8 |
| 6 mg/kg | 3.22 ± 0.181-b | 67.9 ± 6.2c | 13.78 ± 3.691-d | 9 |
↵1-a Vehicle (control) and EEDQ were administered i.p. 6 hr before experiments; values are mean ± S.E.M. of ncells (see “Materials and Methods” for calculations).
↵1-b P < .05, c P < .01 compared to control by one-way analysis of variance followed by Scheffé’s test.
↵1-d P < .05 compared to control by Kruskal Walllis’s test followed by Mann Whitney’s test.