Table 1

Urinary mephenytoin S/R ratios in Han and Bai subjects separated by genotype

Ethnic OriginCYP2C19 GenotypenS/R Ratio
Hanwt/wt 320.17  + 0.03
m1/wt 420.27  + 0.021-b
m2/wt  70.26  + 0.031-c
m1/wt + m2/wt 490.27  + 0.021-b
m1/m1 + m1/m2 + m2/m2 (PMs) 201.00  + 0.021-a
wt/wt + m1/wt + m2/wt (EMs) 810.23  + 0.021-c
Baiwt/wt1020.16  + 0.01
m1/wt 640.27  + 0.021-a
m2/wt  90.24  + 0.031-b
m1/wt + m2/wt 730.26  + 0.021-a
m1/m1 + m1/m2 + m2/m2 + m1/Trp433 (PMs) 270.99  + 0.021-a
wt/wt + m1/wt + m2/wt (EMs)1750.21  + 0.011-b , 1-d
  • 1-a Different from wt/wt (P < .001).

  • 1-b Different from wt/wt (P < .01).

  • 1-c Different from wt/wt (P < .05).0.1

  • 1-d Different from Han ethnic group (P < .05).