L1210 antitumor activity of free and liposomal mitoxantrone in BDF1 mice
| Sample | Drug Dose | Lipid Dose | 60-Day Survival | Mean Survival | ILS1-a | L/F1-b |
|---|---|---|---|---|---|---|
| mg/kg | mg/kg | days | % | |||
| Control | 0 /25 | 8.7 | NA1-c | NA | ||
| Free mitoxantrone | 5 | 0 /10 | 13.6 | 56 | NA | |
| 10 | 0 /10 | 17.2 | 98 | NA | ||
| 20 | 0 /5 | 12.6 | 45 | NA | ||
| DSPC/Chol | 10 | 100 | 0 /9 | 14.7 | 69 | 0.85 |
| 20 | 200 | 0 /10 | 25.1 | 189 | 1.99 | |
| DMPC/Chol | 5 | 50 | 0 /5 | 17.2 | 98 | 1.26 |
| 10 | 100 | 10 /10 | >60 | ND1-d | ND | |
| 20 | 200 | 10 /10 | >60 | ND 1-d | ND |
↵1-a Percentage ILS values were determined from mean survival times of treated and untreated control groups. If the animals survived >60 days, the percentage ILS was not determined.
↵1-b L/F (liposomal/free) values were calculated by dividing the mean survival time of the liposomal formulation by the mean survival time of the free drug at the equivalent dose.
↵1-c NA, not applicable.
↵1-d ND, value could not be determined, based on a 100% survival rate for 60 days.