Tissue | Naive | Saline Pump | Fentanyl Pump |
---|---|---|---|
Liver | 1.80 ± 0.25 | 2.91 ± 0.60 | 3.32 ± 0.96 |
Brain | 6.41 ± 1.92 | 3.31 ± 0.15 | 4.39 ± 0.82 |
Microsomal membranes were prepared, and the concentration of P450 3A was measured by an ELISA assay as detailed under “Methods.” The data are expressed as nanograms of P450 3A per mg protein ± S.E.