Table 1

Summary of ECx and CRIxcalculations at 50% suppression for various combinations of SMX-HA with CSA, FK506 and rapamycin

Drug CombinationsEC50 (in M Test Drug)CRI50
CSA, 0 μM SMX-HA1.31  × 10−7
CSA, 12.5 μM SMX-HA1.95  × 10−8 6.72
CSA, 25 μM SMX-HA2.79  × 10−9 46.95
FK506, 0 μM SMX-HA2.01  × 10−9
FK506, 12.5 μM SMX-HA2.07  × 10−10 9.71
FK506, 25 μM SMX-HA3.13  × 10−11 64.86
Rapamycin, 0 μM SMX-HA1.55  × 10−8
Rapamycin, 12.5 μM SMX-HA1.45  × 10−8 1.06
Rapamycin, 25 μM SMX-HA9.84  × 10−9 1.57